Impacts of Alternative Splicing Events on the Differentiation of Adipocytes

Alternative splicing was found to be a common phenomenon after the advent of whole transcriptome analyses or next generation sequencing. Over 90% of human genes were demonstrated to undergo at least one alternative splicing event. Alternative splicing is an effective mechanism to spatiotemporally ex...

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Main Author:	Jung-Chun Lin
Format:	Article
Language:	English
Published:	MDPI AG 2015-09-01
Series:	International Journal of Molecular Sciences
Subjects:	adipogenesis alternative splicing splicing factor transcriptome analysis
Online Access:	http://www.mdpi.com/1422-0067/16/9/22169

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spelling	doaj-e3dde415b3d545f9b521b51fd715eb822020-11-25T02:01:50ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-09-01169221692218910.3390/ijms160922169ijms160922169Impacts of Alternative Splicing Events on the Differentiation of AdipocytesJung-Chun Lin0School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, TaiwanAlternative splicing was found to be a common phenomenon after the advent of whole transcriptome analyses or next generation sequencing. Over 90% of human genes were demonstrated to undergo at least one alternative splicing event. Alternative splicing is an effective mechanism to spatiotemporally expand protein diversity, which influences the cell fate and tissue development. The first focus of this review is to highlight recent studies, which demonstrated effects of alternative splicing on the differentiation of adipocytes. Moreover, use of evolving high-throughput approaches, such as transcriptome analyses (RNA sequencing), to profile adipogenic transcriptomes, is also addressed.http://www.mdpi.com/1422-0067/16/9/22169adipogenesisalternative splicingsplicing factortranscriptome analysis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jung-Chun Lin
spellingShingle	Jung-Chun Lin Impacts of Alternative Splicing Events on the Differentiation of Adipocytes International Journal of Molecular Sciences adipogenesis alternative splicing splicing factor transcriptome analysis
author_facet	Jung-Chun Lin
author_sort	Jung-Chun Lin
title	Impacts of Alternative Splicing Events on the Differentiation of Adipocytes
title_short	Impacts of Alternative Splicing Events on the Differentiation of Adipocytes
title_full	Impacts of Alternative Splicing Events on the Differentiation of Adipocytes
title_fullStr	Impacts of Alternative Splicing Events on the Differentiation of Adipocytes
title_full_unstemmed	Impacts of Alternative Splicing Events on the Differentiation of Adipocytes
title_sort	impacts of alternative splicing events on the differentiation of adipocytes
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2015-09-01
description	Alternative splicing was found to be a common phenomenon after the advent of whole transcriptome analyses or next generation sequencing. Over 90% of human genes were demonstrated to undergo at least one alternative splicing event. Alternative splicing is an effective mechanism to spatiotemporally expand protein diversity, which influences the cell fate and tissue development. The first focus of this review is to highlight recent studies, which demonstrated effects of alternative splicing on the differentiation of adipocytes. Moreover, use of evolving high-throughput approaches, such as transcriptome analyses (RNA sequencing), to profile adipogenic transcriptomes, is also addressed.
topic	adipogenesis alternative splicing splicing factor transcriptome analysis
url	http://www.mdpi.com/1422-0067/16/9/22169
work_keys_str_mv	AT jungchunlin impactsofalternativesplicingeventsonthedifferentiationofadipocytes
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Impacts of Alternative Splicing Events on the Differentiation of Adipocytes

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