Combination of Hypertension Along with a High Fat and Cholesterol Diet Induces Severe Hepatic Inflammation in Rats via a Signaling Network Comprising NF-κB, MAPK, and Nrf2 Pathways

Combination of Hypertension Along with a High Fat and Cholesterol Diet Induces Severe Hepatic Inflammation in Rats via a Signaling Network Comprising NF-κB, MAPK, and Nrf2 Pathways

Populations with essential hypertension have a high risk of nonalcoholic steatohepatitis (NASH). In this study, we investigated the mechanism that underlies the progression of hypertension-associated NASH by comparing differences in the development of high fat and cholesterol (HFC) diet-induced NASH...

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Bibliographic Details
Main Authors: Yuan Yuan, Hisao Naito, Xiaofang Jia, Kazuya Kitamori, Tamie Nakajima
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Nutrients
Subjects:
hepatic inflammation
high-fat-cholesterol diet
hypertension
mitogen-activated protein kinase
nonalcoholic steatohepatitis
nuclear factor erythroid 2-related factor 2 pathway
nuclear factor-kappa B
spontaneously hypertensive rat
stroke-prone spontaneously hypertensive5/Dmcr
Wistar Kyoto
Online Access:https://www.mdpi.com/2072-6643/9/9/1018

Internet

https://www.mdpi.com/2072-6643/9/9/1018

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