Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model

Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model

Cell biology differs between traditional cell culture and 3-dimensional (3-D) systems, and is modulated by the extracellular matrix. Experimentation in 3-D presents challenges, especially with virulent pathogens. Mycobacterium tuberculosis (Mtb) kills more humans than any other infection and is char...

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Bibliographic Details
Main Authors: Liku B Tezera, Magdalena K Bielecka, Andrew Chancellor, Michaela T Reichmann, Basim Al Shammari, Patience Brace, Alex Batty, Annie Tocheva, Sanjay Jogai, Ben G Marshall, Marc Tebruegge, Suwan N Jayasinghe, Salah Mansour, Paul T Elkington
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
Mycobacterium tuberculosis
extracellular matrix
bioengineering
modelling
Online Access:https://elifesciences.org/articles/21283

Internet

https://elifesciences.org/articles/21283

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