Structural Characterization of Co-Crystals of Chlordiazepoxide with <i>p</i>-Aminobenzoic Acid and Lorazepam with Nicotinamide by DSC, X-Ray Diffraction, FTIR and Raman Spectroscopy

Structural Characterization of Co-Crystals of Chlordiazepoxide with <i>p</i>-Aminobenzoic Acid and Lorazepam with Nicotinamide by DSC, X-Ray Diffraction, FTIR and Raman Spectroscopy

The low water solubility of benzodiazepines seriously affects their bioavailability and, in consequence, their biological activity. Since co-crystallization has been found to be a promising way to modify undesirable properties in active pharmaceutical ingredients, the objective of this study was to...

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Bibliographic Details
Main Authors: Patrycja Garbacz, Dominik Paukszta, Artur Sikorski, Marek Wesolowski
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceutics
Subjects:
chlordiazepoxide
lorazepam
co-crystals
differential scanning calorimetry (DSC)
powder X-ray diffraction (PXRD)
single-crystal x-ray diffraction (SCXRD)
Online Access:https://www.mdpi.com/1999-4923/12/7/648

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https://www.mdpi.com/1999-4923/12/7/648

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