Stem cell niche exit in C. elegans via orientation and segregation of daughter cells by a cryptic cell outside the niche

Stem cells reside in and rely upon their niche to maintain stemness but must balance self-renewal with the production of daughters that leave the niche to differentiate. We discovered a mechanism of stem cell niche exit in the canonical C. elegans distal tip cell (DTC) germ stem cell niche mediated...

Full description

Bibliographic Details
Main Authors: Kacy L Gordon, Jay W Zussman, Xin Li, Camille Miller, David R Sherwood
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/56383