Role of a novel functional variant in the PPP2R1A promoter on the regulation of PP2A-Aalpha and the risk of hepatocellular carcinoma.

Role of a novel functional variant in the PPP2R1A promoter on the regulation of PP2A-Aalpha and the risk of hepatocellular carcinoma.

Previously, we identified the genetic variant -241 (-/G) (rs11453459) in the PP2A-Aα gene (PPP2R1A) promoter and demonstrated that this variant influences the DNA-binding affinity of nuclear factor-kappa B (NF-κB). In this study, we further confirmed that the transcriptional activity of PPP2R1A may...

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Bibliographic Details
Main Authors: Hui-Feng Chen, Jian-Rong Mai, Jian-Xin Wan, Yan-fang Gao, Li-Na Lin, Song-Zi Wang, Yu-Xi Chen, Chen-Zi Zhang, Yu-Jing Zhang, Bin Xia, Kun Liao, Yu-Chun Lin, Zhong-Ning Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3612049?pdf=render

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http://europepmc.org/articles/PMC3612049?pdf=render

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