Pharmacokinetics of a Cholesterol-conjugated Aptamer Against the Hepatitis C Virus (HCV) NS5B Protein

Pharmacokinetics of a Cholesterol-conjugated Aptamer Against the Hepatitis C Virus (HCV) NS5B Protein

Hepatitis C virus (HCV) is the major cause of progressive liver disease such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Previously, we reported that a 29 nucleotide-long 2’-F pyrimidine modified RNA aptamer against the HCV nonstructural protein 5B efficiently inhibited HCV replic...

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Bibliographic Details
Main Authors: Chang Ho Lee, Soo-Han Lee, Ji Hyun Kim, Yook-Hwan Noh, Gyu-Jeong Noh, Seong-Wook Lee
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
aptamer
cholesterol conjugation
HCV
NS5B
pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300397

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http://www.sciencedirect.com/science/article/pii/S2162253116300397

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