Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves

Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves

Inflammation and dysregulation of the immune system are hallmarks of several neurodegenerative diseases. An activated immune response is considered to be the cause of myelin breakdown in demyelinating disorders. In the peripheral nervous system (PNS), myelin can be degraded in an autophagy-dependent...

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Bibliographic Details
Main Authors: Patrick Lüningschrör, Carsten Slotta, Peter Heimann, Michael Briese, Ulrich M. Weikert, Bita Massih, Silke Appenzeller, Michael Sendtner, Christian Kaltschmidt, Barbara Kaltschmidt
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Schwann cells
autophagy
immune response
myelin
PLEKHG5
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00185/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00185/full

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