The Diversity Outbred Mouse Population Is an Improved Animal Model of Vaccination against Tuberculosis That Reflects Heterogeneity of Protection

The Diversity Outbred Mouse Population Is an Improved Animal Model of Vaccination against Tuberculosis That Reflects Heterogeneity of Protection

We vaccinated the Diversity Outbred (DO) population of mice with BCG, the only vaccine currently used to protect against tuberculosis, and then challenged them with M. tuberculosis by aerosol. We found that the BCG-vaccinated DO mouse population exhibited a wide range of outcomes, in which outcomes...

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Bibliographic Details
Main Authors: Sherry L. Kurtz, Amy P. Rossi, Gillian L. Beamer, Dan M. Gatti, Igor Kramnik, Karen L. Elkins
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mSphere
Subjects:
mycobacterium tuberculosis
animal models
diversity outbred
immunization
tuberculosis vaccines
vaccines
Online Access:https://doi.org/10.1128/mSphere.00097-20

Internet

https://doi.org/10.1128/mSphere.00097-20

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