TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice

TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice

Abstract Background Neuroinflammation is an important host defense response to secondary brain injury after intracerebral hemorrhage (ICH). Triggering receptor expressed on myeloid cells 2 (TREM2) confers strong neuroprotective effects by attenuating neuroinflammation in experimental ischemic stroke...

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Bibliographic Details
Main Authors: Shengpan Chen, Jianhua Peng, Prativa Sherchan, Yongjie Ma, Sishi Xiang, Feng Yan, Hao Zhao, Yong Jiang, Ning Wang, John H. Zhang, Hongqi Zhang
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Neuroinflammation
Subjects:
Intracerebral hemorrhage
TREM2
ApoE
Neuroinflammation
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12974-020-01853-x

Internet

http://link.springer.com/article/10.1186/s12974-020-01853-x

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