Restoring Natural Killer Cell Immunity against Multiple Myeloma in the Era of New Drugs

Restoring Natural Killer Cell Immunity against Multiple Myeloma in the Era of New Drugs

Transformed plasma cells in multiple myeloma (MM) are susceptible to natural killer (NK) cell-mediated killing via engagement of tumor ligands for NK activating receptors or “missing-self” recognition. Similar to other cancers, MM targets may elude NK cell immunosurveillance by reprogramming tumor m...

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Bibliographic Details
Main Authors: Gianfranco Pittari, Luca Vago, Moreno Festuccia, Chiara Bonini, Deena Mudawi, Luisa Giaccone, Benedetto Bruno
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
multiple myeloma
immunotherapy
natural killer cells
killer immunoglobulin-like receptors
cytokines
immune checkpoint inhibition
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01444/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01444/full

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