Studying the Binding Modes of Novel 2-Aminopyridine Derivatives as Effective and Selective c-Met Kinase Type 1 Inhibitors Using Molecular Modeling Approaches

Studying the Binding Modes of Novel 2-Aminopyridine Derivatives as Effective and Selective c-Met Kinase Type 1 Inhibitors Using Molecular Modeling Approaches

The mesenchymal epithelial cell transforming factor c-Met, encoded by c-Met proto-oncogene and known as a high-affinity receptor for Hepatocyte Growth Factor (HGF), is one of the receptor tyrosine kinases (RTKs) members. The HGF/c-Met signaling pathway has close correlation with tumor growth, invasi...

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Bibliographic Details
Main Authors: Qianwen Ye, Chenggong Fu, Jiazhong Li
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
c-Met kinase
2-Aminopyridine
3D-QSAR
molecular docking
molecular dynamics simulations
Online Access:https://www.mdpi.com/1420-3049/26/1/52

Internet

https://www.mdpi.com/1420-3049/26/1/52

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