Patchouli alcohol protects against chronic unpredictable mild stress-induced depressant-like behavior through inhibiting excessive autophagy via activation of mTOR signaling pathway

Patchouli alcohol protects against chronic unpredictable mild stress-induced depressant-like behavior through inhibiting excessive autophagy via activation of mTOR signaling pathway

Patchouli alcohol (PA), a tricyclic sesquiterpene, is the major chemical component of patchouli oil. This study investigated the antidepressant-like effect and mechanism of PA in chronic unpredictable mild stress (CUMS). Our results showed that PA markedly attenuated CUMS-induced depressant-like beh...

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Bibliographic Details
Main Authors: Jianyi Zhuo, Baoyi Chen, Chaoyue Sun, Tao Jiang, Zhiwei Chen, Yanlu Liu, Juan Nie, Hongmei Yang, Jingna Zheng, Xiaoping Lai, Ziren Su, Chuwen Li, Yucui Li
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
CUMS
Antidepressant-like effect
patchouli alcohol
mTOR
Autophagy
Synaptic proteins
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220303073

Internet

http://www.sciencedirect.com/science/article/pii/S0753332220303073

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