Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker to Reduce Kidney Uptake of <sup>68</sup>Ga-Labeled DOTA-Conjugated Peptides and Peptidomimetics

Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker to Reduce Kidney Uptake of <sup>68</sup>Ga-Labeled DOTA-Conjugated Peptides and Peptidomimetics

High kidney uptake is a common feature of peptide-based radiopharmaceuticals, leading to reduced detection sensitivity for lesions adjacent to kidneys and lower maximum tolerated therapeutic dose. In this study, we evaluated if the Met-Val-Lys (MVK) linker could be used to lower kidney uptake of <...

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Bibliographic Details
Main Authors: Shreya Bendre, Zhengxing Zhang, Hsiou-Ting Kuo, Julie Rousseau, Chengcheng Zhang, Helen Merkens, Áron Roxin, François Bénard, Kuo-Shyan Lin
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Molecules
Subjects:
radiopharmaceuticals
kidney uptake
cleavable linkers
neutral endopeptidase (NEP)
renal brush border enzymes
prostate-specific membrane antigen (PSMA)
Online Access:https://www.mdpi.com/1420-3049/25/17/3854

Internet

https://www.mdpi.com/1420-3049/25/17/3854

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