Transcriptome Reprogramming of CD11b+ Bone Marrow Cells by Pancreatic Cancer Extracellular Vesicles

Transcriptome Reprogramming of CD11b+ Bone Marrow Cells by Pancreatic Cancer Extracellular Vesicles

Pancreatic cancers (PC) are highly metastatic with poor prognosis, mainly due to delayed detection. We previously showed that PC-derived extracellular vesicles (EVs) act on macrophages residing in the liver, eliciting extracellular matrix remodeling in this organ and marked hepatic accumulation of C...

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Bibliographic Details
Main Authors: Joana Maia, Andreia Hanada Otake, Juliana Poças, Ana Sofia Carvalho, Hans Christian Beck, Ana Magalhães, Rune Matthiesen, Maria Carolina Strano Moraes, Bruno Costa-Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
tumor microenvironment
extracellular vesicles
macrophages
monocytes
metastasis
pancreatic cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.592518/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.592518/full

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