High cyclin E staining index in blastemal, stromal or epithelial cells is correlated with tumor aggressiveness in patients with nephroblastoma.

High cyclin E staining index in blastemal, stromal or epithelial cells is correlated with tumor aggressiveness in patients with nephroblastoma.

PURPOSE: Identifying among nephroblastoma those with a high propensity for distant metastases using cell cycle markers: cyclin E as a regulator of progression through the cell cycle and Ki-67 as a tumor proliferation marker, since both are often deregulated in many human malignancies. METHODOLOGY/PR...

Full description

Bibliographic Details
Main Authors: Dominique Berrebi, Julie Leclerc, Gudrun Schleiermacher, Isabelle Zaccaria, Liliane Boccon-Gibod, Monique Fabre, Francis Jaubert, Alaa El Ghoneimi, Cécile Jeanpierre, Michel Peuchmaur
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2373888?pdf=render

Internet

http://europepmc.org/articles/PMC2373888?pdf=render

Similar Items