Prevention and management of diarrhea associated with naldemedine among patients receiving opioids: a retrospective cohort study

Abstract Background Naldemedine, a novel peripherally-acting mu-opioid receptor antagonist, has improved opioid-induced constipation in randomized controlled trials. The most frequent adverse event of naldemedine is diarrhea, which can cause abdominal pain and often leads to treatment discontinuatio...

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Bibliographic Details
Main Authors: Yusuke Takagi, Gakuji Osawa, Yoriko Kato, Eri Ikezawa, Chika Kobayashi, Etsuko Aruga
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Gastroenterology
Subjects:
Online Access:https://doi.org/10.1186/s12876-020-1173-z