Enantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D<sub>1</sub> Receptor

(1) Background: Two first-in-class racemic dopamine D<sub>1</sub> receptor (D<sub>1</sub>R) positive allosteric modulator (PAM) chemotypes (<b>1</b> and <b>2</b>) were identified from a high-throughput screen. In particular, due to its selectivity for...

Full description

Bibliographic Details
Main Authors: Tim J. Fyfe, Peter J. Scammells, J. Robert Lane, Ben Capuano
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
PAM
Online Access:https://www.mdpi.com/1420-3049/26/13/3799