HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism.

HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism.

<h4>Background</h4>DC-SIGN expressed by dendritic cells captures HIV-1 resulting in trans-infection of CD4(+) T-lymphocytes. However, BSSL (bile-salt stimulated lipase) binding to DC-SIGN interferes with HIV-1 capture. DC-SIGN binding properties of BSSL associate with the polymorphic rep...

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Bibliographic Details
Main Authors: Martijn J Stax, Neeltje A Kootstra, Angélique B van 't Wout, Michael W T Tanck, Margreet Bakker, Georgios Pollakis, William A Paxton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22412885/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22412885/?tool=EBI

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