Exercise Counterbalances Rho/ROCK2 Signaling Impairment in the Skeletal Muscle and Ameliorates Insulin Sensitivity in Obese Mice

Exercise Counterbalances Rho/ROCK2 Signaling Impairment in the Skeletal Muscle and Ameliorates Insulin Sensitivity in Obese Mice

Physical exercise is considered a fundamental strategy in improving insulin sensitivity and glucose uptake in skeletal muscle. However, the molecular mechanisms underlying this regulation, primarily on skeletal muscle glucose uptake, are not fully understood. Recent evidence has shown that Rho-kinas...

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Bibliographic Details
Main Authors: Vitor R. Muñoz, Rafael C. Gaspar, Matheus B. Severino, Ana P. A. Macêdo, Fernando M. Simabuco, Eduardo R. Ropelle, Dennys E. Cintra, Adelino S. R. da Silva, Young-Bum Kim, José Rodrigo Pauli
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
obesity
insulin sensitivity
exercise
Rho-kinase (ROCK)
skeletal muscle
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.702025/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.702025/full

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