Stops making sense: translational trade-offs and stop codon reassignment

<p>Abstract</p> <p>Background</p> <p>Efficient gene expression involves a trade-off between (i) premature termination of protein synthesis; and (ii) readthrough, where the ribosome fails to dissociate at the terminal stop. Sense codons that are similar in sequence to st...

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Bibliographic Details
Main Authors: Elgar Greg S, Lichtenstein Conrad P, Cotton James A, Johnson Louise J, Nichols Richard A, Polly p David, Le Comber Steven C
Format: Article
Language:English
Published: BMC 2011-07-01
Series:BMC Evolutionary Biology
Online Access:http://www.biomedcentral.com/1471-2148/11/227