The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress

The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress

Summary: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer’s disease (AD) and cancer. Howeve...

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Main Authors: Francesco Napoletano, Gloria Ferrari Bravo, Ilaria Anna Pia Voto, Aurora Santin, Lucia Celora, Elena Campaner, Clara Dezi, Arianna Bertossi, Elena Valentino, Mariangela Santorsola, Alessandra Rustighi, Valentina Fajner, Elena Maspero, Federico Ansaloni, Valeria Cancila, Cesare Fabio Valenti, Manuela Santo, Osvaldo Basilio Artimagnella, Sara Finaurini, Ubaldo Gioia, Simona Polo, Remo Sanges, Claudio Tripodo, Antonello Mallamaci, Stefano Gustincich, Fabrizio d’Adda di Fagagna, Fiamma Mantovani, Valeria Specchia, Giannino Del Sal
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports
Subjects:
Drosophila
PIN1
transposons
neurodegeneration
heterochromatin
HP1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721011414

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http://www.sciencedirect.com/science/article/pii/S2211124721011414

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