Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects

Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects

Patricia N Sidharta,1 Meggane Melchior,1 Martin K Kankam,2 Jasper Dingemanse1 1Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil CH-4123, Switzerland; 2Vince and Associates Clinical Research, Overland Park, KS 66211, USA Background: Aprocitentan is an orally active, dual...

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Bibliographic Details
Main Authors: Sidharta PN, Melchior M, Kankam MK, Dingemanse J
Format: Article
Language:English
Published: Dove Medical Press 2019-03-01
Series:Drug Design, Development and Therapy
Subjects:
First-in-human study
endothelin
endothelin receptor antagonist
aprocitentan
pharmacokinetics
pharmacodynamics
Online Access:https://www.dovepress.com/single--and-multiple-dose-tolerability-safety-pharmacokinetics-and-pha-peer-reviewed-article-DDDT

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https://www.dovepress.com/single--and-multiple-dose-tolerability-safety-pharmacokinetics-and-pha-peer-reviewed-article-DDDT

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