Admixed Populations Improve Power for Variant Discovery and Portability in Genome-Wide Association Studies

Admixed Populations Improve Power for Variant Discovery and Portability in Genome-Wide Association Studies

Genome-wide association studies (GWAS) are primarily conducted in single-ancestry settings. The low transferability of results has limited our understanding of human genetic architecture across a range of complex traits. In contrast to homogeneous populations, admixed populations provide an opportun...

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Bibliographic Details
Main Authors: Meng Lin, Danny S. Park, Noah A. Zaitlen, Brenna M. Henn, Christopher R. Gignoux
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Genetics
Subjects:
admixture
statistical power
complex trait genetics
polygenic score
genetic architecture
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.673167/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.673167/full

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