Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis.

Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis.

The mammalian ortholog of yeast Slx4, BTBD12, is an ATM substrate that functions as a scaffold for various DNA repair activities. Mutations of human BTBD12 have been reported in a new sub-type of Fanconi anemia patients. Recent studies have implicated the fly and worm orthologs, MUS312 and HIM-18, i...

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Bibliographic Details
Main Authors: J Kim Holloway, Swapna Mohan, Gabriel Balmus, Xianfei Sun, Andrew Modzelewski, Peter L Borst, Raimundo Freire, Robert S Weiss, Paula E Cohen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3107204?pdf=render

Internet

http://europepmc.org/articles/PMC3107204?pdf=render

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