Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis.
The mammalian ortholog of yeast Slx4, BTBD12, is an ATM substrate that functions as a scaffold for various DNA repair activities. Mutations of human BTBD12 have been reported in a new sub-type of Fanconi anemia patients. Recent studies have implicated the fly and worm orthologs, MUS312 and HIM-18, i...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-06-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC3107204?pdf=render |