Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis

Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis

The formation of new blood vessels requires both polarized cell migration and coordinated control of endothelial cell contacts. Here, Cao and colleagues describe at the sub-cellular level the cytoskeletal and cell junction dynamics regulating these processes upon VEGF-induced cell elongation.

Bibliographic Details
Main Authors: Jiahui Cao, Manuel Ehling, Sigrid März, Jochen Seebach, Katsiaryna Tarbashevich, Tomas Sixta, Mara E. Pitulescu, Ann-Cathrin Werner, Boris Flach, Eloi Montanez, Erez Raz, Ralf H. Adams, Hans Schnittler
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02373-8

Internet

https://doi.org/10.1038/s41467-017-02373-8

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