Advances in Genome Editing and Application to the Generation of Genetically Modified Rat Models

The rat has been extensively used as a small animal model. Many genetically engineered rat models have emerged in the last two decades, and the advent of gene-specific nucleases has accelerated their generation in recent years. This review covers the techniques and advances used to generate genetica...

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Bibliographic Details
Main Authors: Vanessa Chenouard, Séverine Remy, Laurent Tesson, Séverine Ménoret, Laure-Hélène Ouisse, Yacine Cherifi, Ignacio Anegon
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Genetics
Subjects:
rat
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.615491/full