Dihydroartemisinin is a hypoxia-active anticancer drug in colorectal carcinoma cells

Dihydroartemisinin is a hypoxia-active anticancer drug in colorectal carcinoma cells

Tumor hypoxia is one main biological factor that drives resistance to chemotherapy and radiotherapy. To develop a novel strategy for overcoming hypoxia-induced therapy resistance we examined the antineoplastic activity of the reactive oxygen donor Dihydroartemisinin (DHA) in human colon cancer cell...

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Bibliographic Details
Main Authors: Teona eOntikatze, Justine eRudner, René eHandrick, Claus eBelka, Verena eJendrossek
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Oncology
Subjects:
Apoptosis
Autophagy
Puma
hypoxia
Bim
therapy resistance
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00116/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00116/full

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