An in Vivo Mouse Model to Investigate the Effect of Local Anesthetic Nanomedicines on Axonal Conduction and Excitability

An in Vivo Mouse Model to Investigate the Effect of Local Anesthetic Nanomedicines on Axonal Conduction and Excitability

Peripheral nerve blocks (PNBs) using local anesthetic (LA) are superior to systemic analgesia for management of post-operative pain. An insufficiently short PNB duration following single-shot LA can be optimized by development of extended release formulations among which liposomes have been shown to...

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Bibliographic Details
Main Authors: Mihai Moldovan, Susana Alvarez, Christian Rothe, Thomas L. Andresen, Andrew Urquhart, Kai H. W. Lange, Christian Krarup
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Neuroscience
Subjects:
liposomes
peripheral nerve block
threshold-tracking
in vivo imaging
lidocaine
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00494/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00494/full

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