Engineering the flagellar type III secretion system: improving capacity for secretion of recombinant protein

Engineering the flagellar type III secretion system: improving capacity for secretion of recombinant protein

Abstract Background Many valuable biopharmaceutical and biotechnological proteins have been produced in Escherichia coli, however these proteins are almost exclusively localised in the cytoplasm or periplasm. This presents challenges for purification, i.e. the removal of contaminating cellular const...

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Bibliographic Details
Main Authors: Charlotte A. Green, Nitin S. Kamble, Elizabeth K. Court, Owain J. Bryant, Matthew G. Hicks, Christopher Lennon, Gillian M. Fraser, Phillip C. Wright, Graham P. Stafford
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Microbial Cell Factories
Subjects:
Recombinant protein secretion
Flagellar
Strain engineering
Secretion assay
Biotechnology
Synthetic biology
Online Access:http://link.springer.com/article/10.1186/s12934-019-1058-4

Internet

http://link.springer.com/article/10.1186/s12934-019-1058-4

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