Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species.

Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species.

Piperlongumine (PL) is a compound isolated from the piper longum plant. It possesses anti-cancer activities through blocking the transcription factor STAT3 and by inducing reactive oxygen species (ROS) in cancer, but not normal cells. It also inhibits platelet aggregation induced by collagen, but th...

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Bibliographic Details
Main Authors: Hengjie Yuan, Katie L Houck, Ye Tian, Uddalak Bharadwaj, Ken Hull, Zhou Zhou, Mingzhao Zhu, Xiaoping Wu, David J Tweardy, Daniel Romo, Xiaoyun Fu, Yanjun Zhang, Jianning Zhang, Jing-fei Dong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4672935?pdf=render

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http://europepmc.org/articles/PMC4672935?pdf=render

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