Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

Abstract The increased healthspan afforded by coffee intake provides novel opportunities to identify new therapeutic strategies. Caffeine has been proposed to afford benefits through adenosine A2A receptors, which can control synaptic dysfunction underlying some brain disease. However, decaffeinated...

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Bibliographic Details
Main Authors: Mara Yone D. Fernandes, Fernando Dobrachinski, Henrique B. Silva, João Pedro Lopes, Francisco Q. Gonçalves, Felix A. A. Soares, Lisiane O. Porciúncula, Geanne M. Andrade, Rodrigo A. Cunha, Angelo R. Tomé
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-89964-0