Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-Dependent and CD4+ T Cell-Independent CD8+ T-Cell Response Against Unconjugated Protein Antigen

Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-Dependent and CD4+ T Cell-Independent CD8+ T-Cell Response Against Unconjugated Protein Antigen

There is a need for new vaccine adjuvant strategies that offer both vigorous antibody and T-cell mediated protection to combat difficult intracellular pathogens and cancer. To this aim, we formulated class-B synthetic oligodeoxynucleotide containing unmethylated cytosine-guanine motifs (CpG-ODN) wit...

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Bibliographic Details
Main Authors: Ana L. Chiodetti, María F. Sánchez Vallecillo, Joseph S. Dolina, María I. Crespo, Constanza Marin, Stephen P. Schoenberger, Daniel A. Allemandi, Santiago D. Palma, María C. Pistoresi-Palencia, Gabriel Morón, Belkys A. Maletto
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
CpG-ODN
nanostructure
vaccine
adjuvant
CD8+ T-cell response
type I interferons
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02319/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02319/full

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