Activated scavenger receptor A promotes glial internalization of aβ.

Beta-amyloid (Aβ) aggregates have a pivotal role in pathological processing of Alzheimer's disease (AD). The clearance of Aβ monomer or aggregates is a causal strategy for AD treatment. Microglia and astrocytes are the main macrophages that exert critical neuroprotective roles in the brain. The...

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Bibliographic Details
Main Authors: He Zhang, Ya-jing Su, Wei-wei Zhou, Shao-wei Wang, Peng-xin Xu, Xiao-lin Yu, Rui-tian Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3981768?pdf=render