Distinct Modulation of Spontaneous and GABA-Evoked Gating by Flurazepam Shapes Cross-Talk Between Agonist-Free and Liganded GABAA Receptor Activity

Distinct Modulation of Spontaneous and GABA-Evoked Gating by Flurazepam Shapes Cross-Talk Between Agonist-Free and Liganded GABAA Receptor Activity

GABAA receptors (GABAARs) play a crucial inhibitory role in the CNS. Benzodiazepines (BDZs) are positive modulators of specific subtypes of GABAARs, but the underlying mechanism remains obscure. Early studies demonstrated the major impact of BDZs on binding and more recent investigations indicated g...

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Bibliographic Details
Main Authors: Magdalena Jatczak-Śliwa, Katarzyna Terejko, Marek Brodzki, Michał A. Michałowski, Marta M. Czyzewska, Joanna M. Nowicka, Anna Andrzejczak, Rakenduvadhana Srinivasan, Jerzy W. Mozrzymas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
GABAA receptor
γ-aminobutyric acid
benzodiazepines
spontaneous activity
preactivation
gating
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00237/full

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https://www.frontiersin.org/article/10.3389/fncel.2018.00237/full

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