Re-evaluation of the causes of variation among mouse aggregation chimaeras

The composition of adult mouse aggregation chimaeras is much more variable than X-inactivation mosaics. An early theoretical model proposed that almost all the extra variation in chimaeras arises, before X-inactivation occurs, by spatially constrained, geometrical allocation of inner cell mass (ICM)...

Full description

Bibliographic Details
Main Authors: John D. West, Pin-Chi Tang, Clare A. Everett, Gillian E. MacKay, Jean H. Flockhart, Margaret A. Keighren
Format: Article
Language:English
Published: The Company of Biologists 2019-05-01
Series:Biology Open
Subjects:
Online Access:http://bio.biologists.org/content/8/5/bio042804