Neurofibromin Deficiency and Extracellular Matrix Cooperate to Increase Transforming Potential through FAK-Dependent Signaling

Neurofibromin Deficiency and Extracellular Matrix Cooperate to Increase Transforming Potential through FAK-Dependent Signaling

Plexiform neurofibromas (Pnfs) are benign peripheral nerve sheath tumors that are major features of the human genetic syndrome, neurofibromatosis type 1 (NF1). Pnfs are derived from Schwann cells (SCs) undergoing loss of heterozygosity (LOH) at the <i>NF1</i> locus in an <i>NF1<...

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Bibliographic Details
Main Authors: Andrea Errico, Anna Stocco, Vincent M. Riccardi, Alberto Gambalunga, Franco Bassetto, Martina Grigatti, Amedeo Ferlosio, Gianluca Tadini, Debora Garozzo, Stefano Ferraresi, Andrea Trevisan, Sandra Giustini, Andrea Rasola, Federica Chiara
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
neurofibromatosis type 1
tumor therapy
extracellular matrix
FAK
MEK inhibitor
Online Access:https://www.mdpi.com/2072-6694/13/10/2329

Internet

https://www.mdpi.com/2072-6694/13/10/2329

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