AKT1-CREB stimulation of PDGFRα expression is pivotal for PTEN deficient tumor development

AKT1-CREB stimulation of PDGFRα expression is pivotal for PTEN deficient tumor development

Abstract As evidenced by the behavior of loss-of-function mutants of PTEN in the context of a gain-of-function mutation of AKT1, the PTEN-AKT1 signaling pathway plays a critical role in human cancers. In this study, we demonstrated that a deficiency in PTEN or activation of AKT1 potentiated the expr...

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Bibliographic Details
Main Authors: Xiaofeng Wan, Meng Zhou, Fuqiang Huang, Na Zhao, Xu Chen, Yuncui Wu, Wanhui Zhu, Zhaofei Ni, Fuquan Jin, Yani Wang, Zhongdong Hu, Xianguo Chen, Min Ren, Hongbing Zhang, Xiaojun Zha
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03433-0

Internet

https://doi.org/10.1038/s41419-021-03433-0

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