Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells

Mitochondrial metabolism is an attractive target for cancer therapy. Reprogramming metabolic pathways can potentially sensitize tumors with limited treatment options, such as triple-negative breast cancer (TNBC), to chemo- and/or radiotherapy. Dichloroacetate (DCA) is a specific inhibitor of the pyr...

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Bibliographic Details
Main Authors: Sven de Mey, Inès Dufait, Heng Jiang, Cyril Corbet, Hui Wang, Melissa Van De Gucht, Lisa Kerkhove, Ka Lun Law, Hugo Vandenplas, Thierry Gevaert, Olivier Feron, Mark De Ridder
Format: Article
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Online Access:https://www.mdpi.com/1422-0067/21/24/9367