Pic Protein From Enteroaggregative E. coli Induces Different Mechanisms for Its Dual Activity as a Mucus Secretagogue and a Mucinase

Pic Protein From Enteroaggregative E. coli Induces Different Mechanisms for Its Dual Activity as a Mucus Secretagogue and a Mucinase

A hallmark of enteroaggregative Escherichia coli (EAEC) infection is the formation of an intestinal biofilm, which comprises a mucus layer with immersed bacteria. Pic is an autotransporter secreted by EAEC, and other E. coli pathotypes, and has been involved in two apparently contradictory phenotype...

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Bibliographic Details
Main Authors: Fernando Flores-Sanchez, Lucia Chavez-Dueñas, Javier Sanchez-Villamil, Fernando Navarro-Garcia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
autotransporter protein
MUC2
MUC5AC
mucus hypersecretion
mucin cleavage
intracellular calcium
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.564953/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.564953/full

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