Protein Synthesis Inhibition Activity of Mesothelin Targeting Immunotoxin LMB-100 Decreases Concentrations of Oncogenic Signaling Molecules and Secreted Growth Factors

Protein Synthesis Inhibition Activity of Mesothelin Targeting Immunotoxin LMB-100 Decreases Concentrations of Oncogenic Signaling Molecules and Secreted Growth Factors

LMB-100 is a mesothelin-targeted recombinant immunotoxin (iTox) that carries a modified <i>Pseuodomonas</i> exotoxin A (PE) payload. PE kills cells by inhibiting synthesis of new proteins. We found that treatment of pancreatic cancer cells with LMB-100 for 24&#8315;48 h did not chang...

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Bibliographic Details
Main Authors: Salma El-Behaedi, Rebekah Landsman, Michael Rudloff, Emily Kolyvas, Rakan Albalawy, Xianyu Zhang, Tapan Bera, Keith Collins, Serguei Kozlov, Christine Alewine
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Toxins
Subjects:
immunotoxin
pancreatic cancer
VEGF
microenvironment
ubiquitination
Online Access:https://www.mdpi.com/2072-6651/10/11/447

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https://www.mdpi.com/2072-6651/10/11/447

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