Hypermethylation of the PZP gene is associated with hepatocellular carcinoma cell proliferation, invasion and migration

Pregnancy zone protein (PZP), a member of the proteinase inhibitor I39 (‐2‐macroglobulin) family of proteins, is involved in the initiation and development of various tumors. The gene encoding PZP is hypermethylated and expressed at low levels in hepatocellular carcinoma (HCC) tissue and cells, but...

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Bibliographic Details
Main Authors: Minhua Wu, Hui Lan, Zhongwei Ye, Yonghui Wang
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:FEBS Open Bio
Subjects:
HCC
PZP
Online Access:https://doi.org/10.1002/2211-5463.13093