Development and Preclinical Evaluation of an Integrase Defective Lentiviral Vector Vaccine Expressing the HIVACAT T Cell Immunogen in Mice

Development and Preclinical Evaluation of an Integrase Defective Lentiviral Vector Vaccine Expressing the HIVACAT T Cell Immunogen in Mice

Cellular immune responses play a fundamental role in controlling viral replication and AIDS progression in human immunodeficiency virus (HIV)-infected subjects and in simian immunodeficiency virus (SIV)-infected macaques. Integrase defective lentiviral vector (IDLV) represents a promising vaccine ca...

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Bibliographic Details
Main Authors: Alessandra Gallinaro, Martina Borghi, Maria Franca Pirillo, Serena Cecchetti, Roberta Bona, Andrea Canitano, Zuleika Michelini, Antonio Di Virgilio, Alex Olvera, Christian Brander, Donatella Negri, Andrea Cara
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
HIV-1
vaccine
lentiviral vector
immunization
IDLV
integrase defective
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120300243

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http://www.sciencedirect.com/science/article/pii/S2329050120300243

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