KCa3.1/IK1 channel regulation by cGMP-dependent protein kinase (PKG) via reactive oxygen species and CaMKII in microglia: An immune modulating feedback system?

KCa3.1/IK1 channel regulation by cGMP-dependent protein kinase (PKG) via reactive oxygen species and CaMKII in microglia: An immune modulating feedback system?

The intermediate conductance Ca2+-activated K+ channel, KCa3.1 (IK1/SK4/KCNN4) is widely expressed in the innate and adaptive immune system. KCa3.1 contributes to proliferation of activated T lymphocytes and, in CNS-resident microglia, it contributes to Ca2+ signaling, migration and production of pr...

Full description

Bibliographic Details
Main Authors: Roger eFerreira, Raymond eWong, Lyanne eSchlichter
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Immunology
Subjects:
patch-clamp electrophysiology
KCa3.1/KCNN4/IK1/SK4 regulation
cGMP-PKG signaling
reactive oxygen species signaling
Ca2+-CaM-CaMKII signaling
Fura-2 calcium measurement
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00153/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00153/full

Similar Items