Drug Discovery and Development of Novel Therapeutics for Inhibiting TMAO in Models of Atherosclerosis and Diabetes

Diabetes mellitus exists as a comorbidity with congestive heart failure (CHF). However, the exact molecular signaling mechanism linking CHF as the major form of mortality from diabetes remains unknown. Type 2 diabetic patients display abnormally high levels of metabolic products associated with gut...

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Bibliographic Details
Main Authors: Ian Steinke, Nila Ghanei, Manoj Govindarajulu, Sieun Yoo, Juming Zhong, Rajesh H. Amin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Physiology
Subjects:
TMA
CVD
T2D
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.567899/full