IL-33 Promotes CD11b/CD18-Mediated Adhesion of Eosinophils to Cancer Cells and Synapse-Polarized Degranulation Leading to Tumor Cell Killing

IL-33 Promotes CD11b/CD18-Mediated Adhesion of Eosinophils to Cancer Cells and Synapse-Polarized Degranulation Leading to Tumor Cell Killing

Eosinophils are major effectors of Th2-related pathologies, frequently found infiltrating several human cancers. We recently showed that eosinophils play an essential role in anti-tumor responses mediated by immunotherapy with the ‘alarmin’ intereukin-33 (IL-33) in melanoma mouse...

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Bibliographic Details
Main Authors: Sara Andreone, Francesca Spadaro, Carla Buccione, Jacopo Mancini, Antonella Tinari, Paola Sestili, Adriana Rosa Gambardella, Valeria Lucarini, Giovanna Ziccheddu, Isabella Parolini, Cristiana Zanetti, Maria Teresa D’Urso, Adele De Ninno, Luca Businaro, Claudia Afferni, Fabrizio Mattei, Giovanna Schiavoni
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
interleukin (il)-33
eosinophils
degranulation
adhesion
tumor cell killing
mouse tumor models
Online Access:https://www.mdpi.com/2072-6694/11/11/1664

Internet

https://www.mdpi.com/2072-6694/11/11/1664

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