Analysis of Candidate Idarubicin Drug Resistance Genes in MOLT-3 Cells Using Exome Nuclear DNA

Various gene alterations related to acute leukemia are reported to be involved in drug resistance. We investigated idarubicin (IDR) resistance using exome nuclear DNA analyses of the human acute leukemia cell line MOLT-3 and the derived IDR-resistant cell line MOLT-3/IDR. We detected mutations in MO...

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Bibliographic Details
Main Authors: Tomoyoshi Komiyama, Atsushi Ogura, Takehito Kajiwara, Yoshinori Okada, Hiroyuki Kobayashi
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Genes
Subjects:
Online Access:http://www.mdpi.com/2073-4425/9/8/390