Boosting the MHC class II-restricted tumor antigen presentation to CD4+ T helper cells: a critical issue for triggering protective immunity and re-orienting the tumor microenvironment toward an anti-tumor state

Boosting the MHC class II-restricted tumor antigen presentation to CD4+ T helper cells: a critical issue for triggering protective immunity and re-orienting the tumor microenvironment toward an anti-tumor state

Although the existence of an immune response against tumor cells is well documented, the fact that tumors take off in cancer patients indicates that neoplastic cells can circumvent this response. Over the years many investigators have described strategies to rescue the anti-tumor immune response wit...

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Bibliographic Details
Main Authors: Roberto eAccolla, Letizia eLombardo, Rawan eAbdallah, Goutham eRaval, Greta eForlani, Giovanna eTosi
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Oncology
Subjects:
T helper cells
tumor vaccines
anti-tumor immunity
CIITA
MHC class II
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00032/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00032/full

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