Protein Stability, Folding and Misfolding in Human PGK1 Deficiency

Protein Stability, Folding and Misfolding in Human PGK1 Deficiency

Conformational diseases are often caused by mutations, altering protein folding and stability in vivo. We review here our recent work on the effects of mutations on the human phosphoglycerate kinase 1 (hPGK1), with a particular focus on thermodynamics and kinetics of protein folding and misfolding....

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Bibliographic Details
Main Authors: Giovanna Valentini, Maristella Maggi, Angel L. Pey
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Biomolecules
Subjects:
protein misfolding
protein aggregation
conformational disease
pharmacological therapies
molecular chaperones
thermodynamic stability
kinetic stability
proteolysis
Online Access:http://www.mdpi.com/2218-273X/3/4/1030

Internet

http://www.mdpi.com/2218-273X/3/4/1030

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